Seperating the Components of Panacetin

Alex Wilson 9/11/12 experiment 2 Separating the Components of Panacetin Introduction Of the three components likely to be present in your sample of Panacetin ( acetylsalicylic acid, acetanilide, and starch), only starch is insoluble in the organic closure dichloromethane (or methylene chloride), CH2 Cl2. If a sample of Panacetin is dissolved as altogether as possible in dichloromethane, the insoluble starch can be filtered go forth, leaving acetanilide and aspirin in resolving. The purpose of this experiment is to prolong the components of Panacetin.Although the acetanilide and aspirin atomic number 18 both quite insoluble in water at room temperature, the sodium salt of aspirin is truly soluble in water besides insoluble in dichloromethane. Because aspirin is a reasonably strong acid, it can be converted to the salt, sodium acetylsalicylate, by reaction with the basic sodium hydroxide. While the two moulds are thoroughly mixed, the aspirin will react with the sodium hydroxi de in the bottom layer, which thus migrates to the sedimentary layer and can be soft separated in a separatory funnel.Adding some dilute hydrochloric acid to the aqueous resolution restores free aspirin as an insoluble white unanimous evaporating the termination from the bottom layer leaves the acetanilide behind. Experimental For the separation of sucrose, we weighed place 3. 048g of Panacetin onto a filter, and 50 mL of dichloromethane in a convey cylinder. Then we transferred both the panacetin and dichloromethane into an Erlenmeyer flask and stirred it until the panacetin was dissolved. We let it ironical by gravity and set it aside to prohibitionist. The filter paper weighed rough 1. 320g and sucrose weighed out at 1. 028g.Sucrose also ended up on the outside rim of the filter paper. We then proceed to separate the aspirin. We compute 30mL of NaHCO3 and mixed it with 7mL of 6M HCl. We drained the organic layer into a pre-weighed Erlenmeyer flask and bear it for rec overy of acetanilide. We took the combined aqueous extracts in an Erlenmeyer flask, and acidify the aqueous solution by slow plyition, with stirring, of 20 mL of 6M HCl. We made sure the solution is strongly acidic by testing it with litmus paper get a pH of 2. We then cooled the mixture to room temperature swirling the flask now and then in an ice bath.We collected the aspirin by vacuum filtration and wash the aspirin on the filter with cold distilled water. We let it air dry for 30-35 minutes and then weighed the aspirin. It weighed out at 0. 513g. The unknown component was calculated and weighed at 0. 738g. Results When we were mixing the filtration and letting it vent periodically, we lost some of it. So our percent recovery is as follows The unknown component weighed 0. 738g. And our percent physical composition is as follows Discussion Sucrose is insoluble in the organic solvent dichloromethane (CH2 Cl2).Aspirin, acetanilide, and phenacetin are soluble in dichloromethane b ut relatively soluble in water. Aspirin reacts with bases such as sodium bicarbonate to form a salt, sodium acetylsalicylate, which is insoluble in water. acetanilid and phenacetin are not converted into salts by sodium bicarbonate. The reciprocatory (Interconversion) of Aspirin and its Sodium Salt Conclusion The breakdown of Panacetin commixture panacetin with CH2 Cl2 and you will get a solid which is sucrose and youll get a filtrate of aspirin and an unknown substance. Then you will extract the aspirin with NaHCO3 to get an organic layer and a water layer.The bottom layer for us was the organic layer, while the top layer was the water layer. aft(prenominal) figuring out the organic layer you mix the unknown with CH2 Cl2, and then you will evaporate to leave just the unknown substance. When you figure out which layer was the water layer, youll mix sodium salicylate and H2O. You will then add HCl until the pH level of the solution reaches 2. After the pH reaces2, you have aspiri n which proves that as long as you follow the directions in this lab, you will have indeed separated the aspirin from the panacetin.